恩孺醫療團隊最新研究成果

研究犬腎上腺功能亢進症已進入22個年頭, 研究心臟肌肉運動模式已進入12個年頭
這是我們新的研究成果, 謝謝所有飼主的信任與支持讓我們有滿滿的動力  繼續孤單的研究之路 

 

最新研究成果: 犬腎上腺功能亢進症: 高血壓,高血壓終器官症候群 (TOD,蛋白尿與腎臟血管阻力) 與存活率 發表於International Journal of Endocrinology 2016, Volume 2016, Article ID 3814034, 7 pages
http://dx.doi.org/10.1155/2016/3814034 Association of Renal Resistive Index, Renal Pulsatility Index, Systemic Hypertension, and Albuminuria with Survival in Dogs with Pituitary-Dependent Hyperadrenocorticism
  
Hung-Yin Chen, Yu-Hsin Lien, and Hui-Pi Huang
 
Institute of Veterinary Clinical Science, Veterinary School, National Taiwan University, No. 1, Section 4, Roosevelt Road, Taipei 100, Taiwan
Azu Clinic for Animals, No. 92, Section 1, Kin-Shan South Road, Taipei 100,

 

論文摘要

An increased renal resistive index (RI) and albuminuria are markers of target organ damage secondary to systemic hypertension. This study evaluated associations between systemic blood pressure (SBP), renal RI, pulsatility index (PI), and albuminuria in dogs with pituitary-dependent hyperadrenocorticism (PDH). Predictors of overall mortality were investigated. Twenty client-owned dogs with PDH and 20 clinically healthy client-owned dogs as matched controls were included. Incidence rates of systemic hypertension (SBP ≥ 160 mmHg), albuminuria, and increased renal RI (≥ 0.70) and PI (≥ 1.45) in the control group were 5%, 0%, 5%, and 0%, respectively, compared to 35%, 40%, 50%, and 35%, respectively, in the PDH group (, , , and , resp.). No association between systemic hypertension, renal RI, renal PI, and albuminuria was observed. PDH was the only predictor of albuminuria and increased renal RI. Survival was not affected by increased renal PI, systemic hypertension, or albuminuria. Increased renal RI (≥ 0.70) was the only predictor of overall mortality in dogs with PDH.

 

 

最新研究成果: 貓心肌運動模式定義異質性與同步性
 
發表於 Veterinary Medicine: Research and Reports 2016 Volume 2016: 33-40,  7 Pages https://dx.doi.org/10.2147/VMRR.S97634
Two-dimensional speckle-tracking echocardiographic assessment of left ventricular mechanical synchrony in clinically normal cats
 
Yueh-Lun Hsu, Hui-Pi Huang,
 
Institute of Veterinary Clinical Science, Veterinary School, National Taiwan University, No. 1, Section 4, Roosevelt Road, Taipei 100, Taiwan論文摘要

 

Ventricular heterogeneity and synchrony are associated with hypertrophic cardiomyopathy in humans. Hypertrophic cardiomyopathy is commonly observed in cats. The aim of this study was to determine the presence and normal range of left ventricular mechanical heterogeneity and synchrony in clinically healthy cats using two-dimensional speckle-tracking echocardiography. Thirty-four clinically healthy cats were included in this prospective study. Two-dimensional echocardiography and two-dimensional speckle-tracking echocardiography were performed on all cats. Echocardiographic parameters, including circumferential, radial, and longitudinal strain and strain rate, heterogeneity, and synchrony, were measured. Segmental heterogeneity values in the circumferential, radial, and longitudinal directions were 13.1%±5.9%, 19.1%±10.3%, and 15.4%±6.8%, respectively. Transmural heterogeneity was -14.3%±4.6% in the circumferential direction. Left ventricular synchrony values in the circumferential, radial, and longitudinal directions were 11.7±4.2, 16.5±13.4, and 19.4±8.5 ms, respectively. Interventricular synchrony was -3.9±13.2 ms. Left ventricular heterogeneity and synchrony were noted in clinically healthy cats; segmental heterogeneity, which is characterized as longitudinal, progressively increased from the apical to the basal segments, while transmural heterogeneity, which is characterized as circumferential, progressively decreased from the endocardium to the epicardium.

 

 

最新研究成果: 犬腎上腺功能亢進症的心臟病
 
研究犬腎上腺功能亢進症已21年後 終於理解這個致命的病發症所透露的訊息 發表於Acta Vet Scand. 2014 Dec 31;56:88. doi: 10.1186/s13028-014-0088-5.
 
 Assessment of left ventricular function by two-dimensional speckle-tracking echocardiography in small breed dogs with hyperadrenocorticism.
Hung-Yin Chen, Yu-Hsin Lien, and Hui-Pi Huang
 
Institute of Veterinary Clinical Science, Veterinary School, National Taiwan University, No. 1, Section 4, Roosevelt Road, Taipei 100, Taiwan
Azu Clinic for Animals, No. 92, Section 1, Kin-Shan South Road, Taipei 100,

 

論文摘要

 

Hyperadrenocorticism (HAC) is associated with an increased prevalence of hypertension. This study investigated the left ventricular function using two-dimensional speckle-tracking echocardiography (2D-STE) in small breed dogs affected with spontaneous HAC. Age-matched healthy controls (n = 9), dogs with pituitary-dependent hyperadrenocorticism (PDH, n = 10), and dogs with adrenal-dependent hyperadrenocorticism (ADH, n = 9) were included in this study. Conventional echocardiography, global longitudinal and circumferential strain, and strain rate were assessed.

 

On group-wise comparison, left ventricular free wall (LVFWd) and interventricular septal thickness in diastole (IVSd) were thickest in the ADH group, followed by the PDH and controls (P = 0.014 and P = 0.001, respectively). Neither LVFWd nor IVSd was correlated with systemic blood pressure (P = 0.238 and P = 0.113, respectively). The values of all variables derived from the global strain and strain rate in longitudinal and circumferential directions followed the same pattern: highest in the controls, followed by PDH and then ADH (all P < 0.05, respectively). On multiple regression analyses, global longitudinal strain, global longitudinal strain rate in systole and early diastole, and global circumferential strain all decreased linearly with increased IVSd (all P < 0.05).

 

Left ventricular hypertrophy (LVH) was more prevalent in the HAC group compared to the control group. Association between hypertension and development of LVH was not identified. Decreased global longitudinal and circumferential strains were associated with increased IVSd. 2D-STE revealed significant decreases in systolic functions that were undetected using conventional echocardiography in the ADH and PDH groups.